There is a launch of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to lessen afferent discomfort transmission and make analgesia. Thus, medications like clonidine that target alpha-2 receptors can affect the transmission of discomfort. For people who get dizzy when standing: https://www.proleviate.com/post/the-new-pain-killer-conolidine