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Opioid activity is due to the two low affinity binding in the dad or mum compound and better affinity binding with the O-demethylated metabolite M1 to µ-opioid receptors. In animal designs, M1 is up to six times much more potent than tramadol in making analgesia and two hundred moments additional https://derekn631lvb8.thenerdsblog.com/profile

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