Below we demonstrate that DNL343 decreases ISR activation and neurodegeneration brought on acutely by an optic nerve crush (ONC) damage or chronically by a germline eIF2B LOF mutation in mice. We also show that DNL343 treatment, initiated at a late stage of sickness which extra precisely replicates a medical dosing https://bdp529021098.topbloghub.com/34477789/the-definitive-guide-to-vbit-12